Research Associate I, Analytical Development Formulation

Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.

At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.

We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, Germany, and Spain.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.

Our principles:

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

Position Overview

The Research Associate I, Analytical Development Formulation , reporting to a Scientist in Analytical Development Formulation, will be responsible for the development and execution of biochemical, biophysical, and molecular biology assays to support formulation development, robustness and stability of non-clinical recombinant Adeno-associated virus (rAAV) vectors. Furthermore, the selected candidate will also participate in supporting process development in-process analytics. This individual will also participate in analytical test method development, qualification, and validation support along with analytical method tech transfer for future non-GMP and GMP drug product release, when needed. The ideal candidate will have experience with ELISA, PCR assays, HPLC (e.g. SEC, RP), and/or DLS. This position will be based at our headquarters facility in RTP (Durham), North Carolina.

Responsibilities

• Execution of developed analytical assays including ELISA, HPLC (SEC), DLS, ddPCR and cell-based assays.

• Contributes to the development of analytical assays for formulation development.

• Participates in testing to support method development and product characterization.

• Contributes to test methods, reports and developmental reports.

• Perform routine instrument maintenance and performance verification.

• Responsible for maintaining clear, organized, and detailed laboratory notebooks.

• Perform data analysis and effectively communicate results in formal reports and presentations for internal discussions.

• Ensure lab areas are clean and organized and that equipment, supplies and raw materials are available for use.

• Assist in writing Standard Operating Procedures (SOPs) to support development and analytical testing needs.

Required Education and Experience

• BS degree in Biology, Molecular or Cellular Biology, Biochemistry, Chemistry, or relevant field

• Excellent interpersonal skills with the ability to interact effectively with people

• Proficiency in Microsoft Office Suite (Word, Excel, PowerPoint)

Preferred Experience and Skills

• Self-motivated, organized, capable of working independently as well as in a collaborative environment with cross-disciplinary teams

• Possess knowledge of and experience with mammalian cell culture, ELISA, ddPCR, DLS, and/or HPLC

• Technical lab skills with attention to detail

• Ability to multitask among multiple projects and teams, and work in a fast-paced, highly interactive environment.

• Strong oral and written communication skills

• Ability to innovate and use good judgment to achieve a solution

• Relevant knowledge of AAV gene therapy vectors or other complex biologics

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email at careers@askbio.com .

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.